Contents, viagra (Sildenafil Citrate) edit, sildenafil Citrate, more commonly known as Viagra, is a drug that is used to treat erectile dysfunction viagra sildenafil and pulmonary arterial hypertension (PAH). The viagra sildenafil main function of the sildenafil uk online sildenafil uk online drug is to inhibit the enzyme that degrades cGMP, a regulator of blood flow to the penis. The medical uses for Sildenafil Citrate are viagra sildenafil sexual dysfunction, pulmonary hypertension, and altitude sickness. In viagra sildenafil 1998, the drug Viagra was introduce as an effective way to treat male erectile dysfunction (MED). It goes by the generic name of sildenafil citrate. It has quickly become one of the most popular and most prescribed drugs in the world. Its annual sales account for over a billion dollars each year. Sildenafil was synthesized by a group of pharmaceutical viagra sildenafil chemists working at Pfizers research facility in England. It was discovered by accident while attempting to produce a drug to treat coronary heart disease. It became the first oral treatment accepted by the FDA to treat MED. Physical Properties edit, sildenafil citrate is designated chemically as citrate. Sildenafil citrate is a white to off-white crystalline powder with a solubility.5 mg/mL in water and a molecular weight of 666.7. Viagra (sildenafil citrate) is formulated as blue, film-coated rounded-diamond-shaped tablets. Step-by-step synthesis of Viagra, mechanism edit, the mechanism of Viagra (sildenafil) in the body involves the protection of cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum of the male penis. First, nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors. This results in an increase of cGMP, which sildenafil uk online promotes vasodilation of the intimal cushions of the helicine arteries. Vasodilation of the intimal cushions allows for an increased blood flow into the spongy tissue of the penis, thus, causing the erectile tissue to expand and create an erection. Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5 which is responsible for degradation of cGMP in the corpus cavernosum. Once cGMP levels deplete, then sildenafil uk online the intimal cushions of the helicine arteries are not able to dilate to allow more blood flow. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Alcohol edit, ethanol and sildenafil cause similar reactions within the body. Therefore, doctors do not recommend consuming alcoholic beverages while taking the drug. Ethanol thins blood and dilates blood vessels which can cause dizziness, rapid heart rate, and low blood pressure. Sildenafil causes the same effect on the body which can cause a dramatic increase in the potential of suffering these effects. It belong to a family of drugs called PDE5 inhibitors. Sildenafil acts by inhibiting cyclic guanosine monophosphate(cGMP)-specific phosphodiesterase type 5, an enzyme which is responsible for degradation of cGMP in the corpus cavernosum in the penis. Nitric oxide in the corpus caverosum then binds to guanylate cyclase receptors, which leads to increased levels of cGMP, leading to smooth muscle relaxation. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Sildenafil is metabolised by liver sildenafil uk online enzymes and excreted by both the liver and kidneys. If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. Reactivity edit, this molecule is very sensitive to temperature and light therefore it has to be kept at room temperature between 15-30 degrees C away from moisture or heat. Also if exposed to prolonged period of time to light it can cause a molecular reaction. Erectile dysfunction (ED) edit, erectile dysfunction is a sexual dysfunction which is shown by the inability to maintain an erection of the penis during sexual intercourse. Because penile erection is a hydraulic effect of blood rushing into the penis and retained in sponge-like pores, erectile dysfunction is cause by circulatory mishap. One of the causes of ED is the modification of voltage-gated potassium channels, which play a major role in action potentials during depolarization. However, there are many other causes of ED such as diabetes, hormonal deficiencies, and neurological problems. Major drugs that are believed to cure ED are Viagra, Cialis, and Levitra and are under competition in the pharmaceutical market. Treatment edit, according to a research, erectile dysfunction increases with passing age. Approximately 20 by the age of 60, though in the 21st century psychological factors such as (stress, depression and anxiety medication, disease and injury is speeding up the process earlier then age. It is estimated than 70 of the population in United States suffer from erectile dysfunction due to an underlying disease like kidney condition.

Sildenafil for erectile dysfunction

For other uses, see. Sildenafil, sold as the sildenafil for erectile dysfunction brand name. Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. 3, its effectiveness for treating sexual dysfunction in women has not been demonstrated. 3, common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing sildenafil for erectile dysfunction loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate as this may result in a severe and potentially fatal drop in blood pressure. 3, sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5 an enzyme that promotes degradation sildenafil for erectile dysfunction of cGMP, which regulates blood flow in the penis. Pfizer scientists, andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. 4 5, since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra). Contents Medical uses 50mg tablets of sildenafil Sexual sildenafil for erectile dysfunction dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. 6 Antidepressant-associated sexual dysfunction Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. 7 Pulmonary hypertension While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014. 8 Raynaud's phenomenon Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 9 10 these drugs have moderate efficacy for reducing the frequency and duration. 9 As of 2016, their role more generally in Raynaud's was not clear. 10 Adverse effects In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. 2 Some sildenafil users have complained of seeing everything tinted blue ( cyanopsia ). 11 Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases 12 and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. 13 Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. 2 In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. 14 Interactions Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma sildenafil for erectile dysfunction levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. 2 Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an 1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy ) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least. 15 Contraindications Contraindications include: 2 :11 Concomitant use of nitric oxide donors, organic nitrites and nitrates, 16 such as: Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Known hypersensitivity to sildenafil Sildenafil should not be used if sexual activity is inadvisable due. Citation needed Nonmedical use Recreational use Sildenafil's popularity with young adults has increased over the years. 17 Sildenafil's trade name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. 18 The reasons behind such use include the belief that the drug increases libido, improves sexual performance, 18 or permanently increases penis size. 19 Studies on the effects of viagra when used recreationally are limited, but suggest it has little effect when used by those not suffering from erectile dysfunction. In one study, a 25-mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. 20 This study also noted a significant placebo effect in the control group. 20 Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs.

Sildenafil citrate dosage men

For other uses, see. Sildenafil, sold as the brand name. Viagra among others, is a medication used to treat erectile dysfunction and sildenafil citrate dosage men pulmonary arterial hypertension. 3, its effectiveness for treating sexual dysfunction in women has not been demonstrated. 3, common side effects include headaches and heartburn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin (glycerin trinitrate as this may result in a severe and potentially fatal drop in blood pressure. 3, sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE5 an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis. Pfizer scientists, andrew Bell, David Brown, and Nicholas Terrett originally discovered sildenafil as a treatment for various cardiovascular disorders. 4 5, since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction; its primary competitors are tadalafil (trade name Cialis) and vardenafil (Levitra). Contents Medical uses 50mg tablets of sildenafil Sexual dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now one of the standard treatments for erectile dysfunction, including for men with diabetes mellitus. 6 Antidepressant-associated sexual dysfunction Tentative evidence suggests that sildenafil may help men who experience antidepressant -induced erectile dysfunction. 7 Pulmonary hypertension While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014. 8 Raynaud's phenomenon Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon ; 9 10 these drugs have moderate efficacy for reducing the frequency and duration. 9 As of 2016, their role more generally in Raynaud's was not clear. 10 Adverse effects In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. 2 Some sildenafil users have complained of seeing everything tinted blue ( cyanopsia ). 11 Some complained of blurriness and loss of peripheral vision. In July 2005, the FDA sildenafil citrate dosage men found that sildenafil could lead to vision impairment in rare cases 12 and a number of studies have linked sildenafil use with non-arteritic anterior ischemic optic neuropathy. 13 Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. 2 In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. 14 Interactions Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours. 2 Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an 1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy ) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least. 15 Contraindications Contraindications include: 2 :11 Concomitant use of nitric oxide donors, organic nitrites and nitrates, 16 such as: Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Known hypersensitivity to sildenafil Sildenafil should not be used if sexual activity is inadvisable due. Citation needed Nonmedical use Recreational use Sildenafil's popularity with young adults has increased over the years. 17 Sildenafil's trade name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. 18 The reasons behind such use include the belief that the drug increases libido, improves sexual performance, 18 or permanently increases penis size. 19 Studies on the effects of viagra when used recreationally are limited, but suggest it has little effect when used by those not suffering from erectile dysfunction. In one study, a 25-mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. 20 This study also noted a significant placebo effect in the control group. 20 Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs. 21 Sildenafil is sometimes used to counteract the effects of other substances, often illicit. 18 Some users mix it with methylenedioxymethamphetamine ( mdma, ecstasy other stimulants, or opiates in an attempt to compensate for the common side effect of erectile dysfunction, a combination known as " sextasy "rockin' and rollin or "trail mix". 18 Mixing with amyl nitrite is particularly dangerous and potentially fatal. 18 Jet lag research The 2007 Ig Nobel Prize in Aviation sildenafil citrate dosage men went to Patricia. Plano, and Diego. Golombek of Universidad Nacional de Quilmes, Argentina, for their discovery that sildenafil helps treat jet lag recovery in hamsters. 22 23 Sports Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles. In turn, they believe it will enhance their performances. 24 25 Analogs Acetildenafil and other synthetic structural analogs of sildenafil which are PDE5 inhibitors have been found as adulterants in a number of "herbal" aphrodisiac products sold over-the-counter. 26 These analogs have not undergone any of the rigorous testing that drugs like sildenafil have passed, and thus have unknown side-effect profiles. 27 Some attempts have been made to ban sildenafil citrate dosage men these drugs, but progress has been slow so far, as, even in those jurisdictions that have laws targeting designer drugs, the laws are drafted to ban analogs of illegal drugs of abuse, rather than analogs of prescription. However, at least one court case has resulted in a product being taken off the market.

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